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The superior selectivity of RB1 in enzyme and mobile-primarily based assays for the inhibition of JAK3 more than one other a few JAK isoforms may well are reached because of the irreversible covalent binding to Cys909 in JAK3, and that is a Ser residue in the other a few JAKs. We incubated JAK3 with RB1, as well as ensuing mixture was subjected to

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